The US embassy said in a statement that the funding would be channelled through the United Nations World Food Programme (WFP).
This is additional support for pregnant and breastfeeding women and people living with HIV or with Tuberculosis.
The US contribution would go towards the purchase, transport and distribution of "huge quantities" of various fortified foods for the treatment of malnutrition in more vulnerable groups, including children under five years of age, whose situation has worsened with the recent prolonged drought event.
It would enable 170 health centres in the most affected southern provinces of Gaza and Inhambane and central Manica, Sofala and Tete to provide nutritional assistance to 21,000 people throughout
"The United States is committed to supporting the people of Mozambique during these difficult times," said US ambassador to Mozambique, Dean Pittman.
According to the statement, People Living with HIV are particularly vulnerable to food insecurity and malnutrition as “it turns out that the anti-retroviral medication they take becomes more effective when combined with good nutrition”.
"US support will increase the absorption, adherence, and success of treatment among the most vulnerable groups," said WFP representative Karin Manente.
The support now granted comes from the US President's Emergency Plan for AIDS Relief (PEPFAR), through the United States Agency for International Development (USAID).
Mozambique is one of 22 countries in Africa supported by PEFPAR and one of the eight UNAIDS priority countries in the southern Africa region, "where it is necessary" to accelerate efforts to eradicate AIDS by 2030.