The Rwandan Health ministry said that the move is aimed at addressing widespread public concerns on the growing use of skin-bleaching chemicals.
The campaign, initiated by Health officials and the Rwanda National Police is also aimed at preventing the effects of ill-health from such prohibited chemicals, it said.
Public Health officials indicate that while the administration of the chemicals is rarely professional, users are exposed to high risks, where their negative impacts, consist mainly of skin related cancers.
In the meanwhile, dermatologists have also warned against the use of such cosmetics as they contain harmful substances such as hydroquinone.
Reports indicate that although hydroquinone was banned in Rwanda, it is still available on the market.
Other chemicals and substances used for skin lightening include Corticosteroids, which is mostly available in some cosmetics like Mediven and Mercury, according to the Rwandan health officials.
The campaign aims to rid the East African country of skin bleaching creams on the list of 1,343 prohibited brands, it said.
Skin-bleaching is common in Africa and other parts of the world with high concentrations of black people.
In Africa, at least four in ten women bleach, according to the World Health Organization.